Node.js remains a highly valuable skill for full-stack web developers despite recent claims of its replacement by Deno. While Deno shows promise, Node.js's established position ensures its continued relevance for job prospects and product development. The video focuses on learning Node.js fundamentals through seven steps, culminating in building a full-stack web application. This hands-on approach emphasizes practical learning by creating something meaningful. The presenter also notes that skills learned in Node.js will largely transfer to Deno in the future.